Homeodomain-Mediated β-Catenin-Dependent Switching Events Dictate Cell-Lineage Determination

نویسندگان
چکیده

منابع مشابه

Homeodomain-Mediated β-Catenin-Dependent Switching Events Dictate Cell-Lineage Determination

While the biological roles of canonical Wnt/beta-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of beta-catenin remains a major challenge. Here, we report an unexpected strategy for beta-catenin-dependent regulation of cell-lineage determinat...

متن کامل

Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A.

Cortical efferents growing in the same environment diverge early in development. The expression of particular transcription factors dictates the trajectories taken, presumably by regulating responsiveness to guidance cues via cellular mechanisms that are not yet known. Here, we show that cortical neurons that are dissociated and grown in culture maintain their cell type-specific identities defi...

متن کامل

Lineage-specific requirements of β-catenin in neural crest development

Beta-catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream signaling component of Wnt that controls multiple developmental processes such as cell proliferation, apoptosis, and fate decisions. To study the role of beta-catenin in neural crest development, we used the Cre/loxP system to ablate beta-catenin specifically in neural crest stem cells. Although s...

متن کامل

β-catenin-mediated inhibition of cross-priming

Cross-priming plays a major role in generating CD8+ T cell-dependent antitumor immunity through cross-presentation. However, the cross-presentation of tumor-associated antigens by dendritic cells often promotes tolerance rather than CD8+ T-cell immunity. We have now identified a β-catenin-dependent pathway of cross-priming inhibition as a novel and potentially broad mechanism whereby neoplastic...

متن کامل

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

During late Schwann cell development, immature Schwann cells segregate large axons from bundles, a process called "axonal radial sorting." Here we demonstrate that canonical Wnt signals play a critical role in radial sorting and assign a role to Wnt and Rspondin ligands in this process. Mice carrying β-catenin loss-of-function mutations show a delay in axonal sorting; conversely, gain-of-functi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Cell

سال: 2006

ISSN: 0092-8674

DOI: 10.1016/j.cell.2006.02.046